It can worsen sedation already caused by the opioid. U.S. Food and Drug Administration. Read our, Plaquenil (Hydroxychloroquine): Uses, Dosage, Side Effects, Precautions, Lybalvi (Olanzapine and Samidorphan) - Oral. WebMD does not provide medical advice, diagnosis or treatment. J Chromatogr. ; US.Patent 2,474,796; June 28, 1949; assigned to This tool may not cover all possible drug interactions. Tell your healthcare provider if you have any of the following: Dicyclomine is a pregnancy category B drug, meaning that no harm was reported in animal studies but studies in humans are lacking. National Kidney Foundation. Its available as a pill (tablet and capsule), liquid solution, and injection. Its best to avoid combining ibuprofen with methotrexate, especially at high doses or for a long time. If it is near the time of the next dose, skip the missed dose. As for the combination of Adderall and Ibuprofen, it does not lead to drug interactions. Dicyclomine - How long does it take for it to take effect? RxList does not provide medical advice, diagnosis or treatment. Dosage of drugs is not considered in the study. In Canada - Call your doctor for medical advice about side effects. Further information Dicyclomine uses and warnings Ibuprofen uses and warnings Similar questions Should I try dicyclomine?! 1997 Feb 12;320(2-3):209-14. Sign in to your account to save this drug interaction list. 2000 Sep-Oct;7(5):287-92. doi: 10.1101/lm.34900. If youre taking blood thinners, your healthcare provider may recommend a different pain medication, like acetaminophen (Tylenol). Bisphosphonate. You should avoid taking ibuprofen if youre taking daily low-dose aspirin. Examples of ACE inhibitors include lisinopril (Zestril) and ramipril (Altace). Some may just need extra monitoring. This is why you should remain sitting upright or standing for 30 to 60 minutes after a dose. What You Need to Know About Bentyl (Dicyclomine). eHealthMe is studying from 210,443 Ibuprofen users for its effectiveness, alternative drugs and more. To relieve dry eyes, consult your pharmacist for artificial tears or other eye lubricants. By providing your email address, you agree to receive emails containing coupons, refill reminders and promotional messages from GoodRx. Thank you, {{form.email}}, for signing up. Be sure to check the list of ingredients on OTC products before taking them. Luckily, its unlikely youll be prescribed this combination of medications. Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Ibuprofen is used to treat the following conditions. If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Wait 30 to 60 minutes before taking any other medications or eating food. If either of these side effects occurs, do not drive, use machines, or do anything else that could be dangerous if you are not alert. Tell your healthcare provider about all medications, supplements, and vitamins you take before starting Bentyl. [, Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. If youre concerned about an ibuprofen interaction, talk to your healthcare provider. It can interact with many medications and cause a variety of symptoms. This combination should be avoided. (2022). Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. If you are taking either ketoconazole or itraconazole, take it at least 2 hours before dicyclomine. No alcohol/food interactions were found. Das S, Mondal S, Datta A, Bandyopadhyay S. A rare case of dicyclomine abuse. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. In serious cases, it can cause seizures or heart problems. Talk to your pharmacist for more details. They can help you decide whether both medications are needed. Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.3,4,5,6 Though it is commonly prescribed, its recommendation may have been based on a small amount of evidence and so its prescription is becoming less favourable.7, Dicyclomine was granted FDA approval on 11 May 1950.6, Dicyclomine is indicated for the treatment of functional bowel disorder and irritable bowel syndrome.6, Dicyclomine is an anticholinergic drug used to relax the smooth muscles of the intestines.6 It's duration of action is not especially long as it is usually taken 4 times daily with individual doses of 20-40mg orally or 10-20mg by intramuscular injection.6 Dicyclomine should not be administered intravenously.6, Dicyclomine achieves its action partially through direct antimuscarinic activity of the M1, M3, and M2 receptors; and partially through antagonism of bradykinin and histamine.3,4,5,6 Dicyclomine non-competitively inhibits the action of bradykinin and histamine, resulting in direct action on the smooth muscle, and decreased strength of contractions seen in spasms of the ileum.4, The bioavailability of dicyclomine has not been determined,2 though it is likely well absorbed as the primary route of elimination is in the urine.1,6 Dicyclomine has a Tmax of 1-1.5h.6, The volume of distribution for a 20mg oral dose is 3.65L/kg.6, Data regarding plasma protein binding of dicyclomine is not readily available.6, The metabolism of dicyclomine has not been well researched.1, Dicyclomine is 79.5% eliminated in the urine and 8.4% in the feces.1,6, The mean plasma elimination half life is approximately 1.8 hours.1,6, Data regarding the clearance of dicyclomine is not readily available.6, Patients experiencing an overdose may present with headache, nausea, vomiting, blurred vision, dilated pupils, dizziness, dry mouth, difficulty swallowing, CNS stimulation, as well as hot, dry skin.6 Treat patients with gastric lavage, emetics, activated charcoal, sedatives for excitement, and a cholinergic agent if indicated.6. Dicyclomine. You should also keep an eye out for OTC combination products that include pain relievers. The phase IV clinical study analyzes what interactions people who take Bentyl and Ibuprofen have. Drug interactions with dicyclomine im and ibuprofen-diphenhydramine citrate oral. These include anticholinergics and medications that affect gastrointestinal motility. Tell your doctor or pharmacist about all the products you take, including: other anticholinergic drugs (such as atropine, glycopyrrolate, scopolamine), other antispasmodic drugs (such as clidinium, propantheline), belladonna alkaloids, certain drugs used to treat Parkinson's disease (such as trihexyphenidyl), certain drugs used to treat irregular heart rhythms (such as disopyramide, quinidine), MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine), phenothiazines (such as chlorpromazine), tricyclic antidepressants (such as amitriptyline). And thats true when it comes to taking NSAIDs together. Bentyl has active ingredients of dicyclomine hydrochloride. (2022). This medication works by slowing the natural movements of the gut and by relaxing the muscles in the stomach and intestines. It can treat pain, fever, and inflammation (swelling). This medicine is a blue, round, tablet imprinted with "M D6". They can also be prescribed to help lower blood pressure. I would also like to sign up for a free GoodRx account, Written by Wiktoria Jedrzejczyk, PharmD Candidate, Written by Nicole E. Cieri-Hutcherson, PharmD, BCPS, NCMP, Written by Jennifer Gershman, PharmD, CPh, PACS, Written by Sonia Amin Thomas, PharmD, BCOP, Written by Ross Phan, PharmD, BCACP, BCGP, BCPS. They work by blocking the actions of a chemical in the body called acetylcholine. With structured adverse effects data, including: Improve decision support & research outcomes with our structured adverse effects data. Do not store in the bathroom. Do not double the dose to catch up. For example, histamine-2 antagonists (H2 blockers), like famotidine (Pepcid AC, Zantac 360) or cimetidine, may be an option. Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, unusual excitement, constipation, fast heartbeat, and urination problems. Build, train, & validate predictive machine-learning models with structured datasets. Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome. This means that taking antacids could make dicyclomine less effective. Wu, A., et al. Danhof I, Schreiber E, Wiggans D, Leyland H: Metabolic dynamics of dicyclomine hydrochloride in man as influenced by various dose schedules and formulations Toxicology and Applied Pharmacology. This is not a complete list of possible side effects. Doing so can reduce the absorption and effectiveness of Bentyl. Eur J Pharmacol. These include latanoprost (Xalatan), timolol (Timoptic), and dorzolamide (Trusopt). Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Now, youll enjoy a streamlined experience created specifically for healthcare providers. Check for more interactions with the Drug Interaction Checker, Never use this combination of drugs because of high risk for dangerous interaction, Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed, Potential for significant interaction (monitoring by your doctor is likely required), Interaction is unlikely, minor, or nonsignificant. This combination can also cause kidney damage. Do not share this medication with others. Ibuprofen interacts with methotrexate by causing higher methotrexate levels in the body. National Library of Medicine: DailyMed. Diuretics (water pills) are medications that help remove extra fluid from the body. This could be mild, like gum bleeding after brushing your teeth. NSAIDs may reduce the blood pressure lowering effects of these antihypertensive medications. RemedyRepack Inc. (2022). Notify your healthcare provider if you become pregnant while taking dicyclomine. Bisphosphonates taken orally, such as alendronate (Fosamax), ibandronate (Boniva) and risedronate (Actonel, Atelvia) Pain relievers, such as ibuprofen (Advil, Motrin IB, others) and aspirin. Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Dicyclomine is FDA approved to help treat symptoms of irritable bowel syndrome (IBS). If youre starting dicyclomine, talk to your healthcare provider about whether any of your other medications have anticholinergic activity. It is often used in pain. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Minimally clinically significant. It helps to reduce the symptoms of stomach and intestinal cramping. . How effective is Metformin Hydrochloride for Blood Glucose Monitoring? Atamet Oral (carbidopa-levodopa oral) atracurium iv. Alcohol may increase drowsiness caused by dicyclomine. Dicyclomine - I am scared to take this medication, but scared to take any medication is there crazy? You should avoid this interaction if possible. Robert Burakoff, MD, MPH, is board-certified in gastroentrology. About GI motility. Automatically receive FDA alerts, drug interaction warnings, plus data on food, allergy & condition interactions. Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum. These include anticholinergics and medications that affect gastrointestinal motility. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Do not start, stop, or change the dosage of any medicines without your doctor's approval. If the next dose is soon, skip the missed dose and continue as normal. All rights reserved. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The most common treatment for glaucoma is eye drops. : Omeprazole is used to suppress acid production in your stomach. If you have a higher risk of ulcers or stomach bleeding, they may ask you to avoid ibuprofen. Common interactions include diarrhoea among females and anxiety among males. StatPearls. This could cause you to have higher blood pressure, which can be dangerous. Store at room temperature away from light and moisture. They may also recommend a different PPI that's less likely to interact. Include all prescription medications, OTC products, and supplements. So, when you combine it with other medications that thin your blood, there is a higher chance of bleeding. Yes, you can take that also. Lithium toxicity. Bentyl should never be used in children under 6 months of age as it can severely slow breathing and lead to acute respiratory distress. Dicyclomine: dicyclomine hydrochloride tablet [drug label]. Please check with a physician if you have health questions or concerns. Dicyclomine belongs to a class of drugs known as anticholinergics/antispasmodics.This medication must not be used by children younger than 6 months old because of the risk of serious side effects. Your healthcare provider may suggest using a different pain medication. Still, your healthcare provider can help ensure youre avoiding this interaction. They're used to treat many different conditions, including anxiety. Get prescription saving tips and more from GoodRx Health. However, this does not necessarily mean no interactions exist. Its available OTC in tablet, capsule, and liquid forms. Ans: This medicine minimises the natural movement of gout loosening up the stomach and intestine muscles. ibuprofen-diphenhydramine citrate oral brand names and other generic formulations include: dicyclomine im and ibuprofen-diphenhydramine citrate oral both decrease additive side effects that may cause blurred vision, increased saliva, and increased bowel movements and urination. Learn about drug interactions between dicyclomine im and ibuprofen-diphenhydramine citrate oral and use the RxList drug interaction checker to check drug combinations. It is very rare for people to become addicted to Bentyl, but some studies have shown that people can grow physically dependent on it. It is based on dicyclomine hydrochloride and ibuprofen (the active ingredients of Bentyl and Ibuprofen, respectively), and Bentyl and Ibuprofen (the brand names). 1 Many multi-symptom medications also contain acetaminophen and should not be taken with Tylenol or generic acetaminophen. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Tests to measure kidney function, damage and detect abnormalities. Dicyclomine can be used both in adults and children and is available as a tablet, capsule, syrup, or injection. Lithium (Lithobid) is commonly used to treat bipolar disorder. They both treat high blood pressure and other heart conditions. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Lacy, B. E., et al. Verywell Health's content is for informational and educational purposes only. Others like metoclopramide (Reglan) may speed up GI motility. You may not need a medication change. This minimizes the cramping you might experience with IBS. Drink plenty of fluids. It is often used in irritable bowel syndrome. As with all drugs, Bentyl can cause side effects ranging from mild to severe. Read More. : Dicyclomine can slow bowel function down and so can hydrocodone and thus the combined effect of the two medications when used together can be constipation.Thus and if both are in use, i would be careful and watch out for slowed bowel function that can lead to constipation.Alert health care professional accordingly should change of bowel habits begin to occur if the above . By providing your email address, you agree to receive emails containing coupons, refill reminders and promotional messages from GoodRx. Selected from data included with permission and copyrighted by First Databank, Inc. Bryant Ranch Prepack. Dr. Tri Huynh answered. The Bentyl dose is measured in milligrams (mg). They can recommend how to safely take it or suggest an alternative medication. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dicyclomine + ibuprofen before they complete the sale. Citrate oral and use the rxlist drug interaction list and promotional messages from GoodRx Health medicine... Talk to your healthcare provider about whether any of your other medications that affect gastrointestinal.. Is why you should also keep an eye out for OTC combination products that include pain relievers same!, it does not necessarily mean no interactions exist case of dicyclomine abuse suggest alternative... Know about Bentyl ( dicyclomine ) about side effects ranging from mild to severe blood... Clear vision until you can do it safely many different conditions, anxiety. Of drugs is not intended to be a substitute for professional medical advice about side.... Include pain relievers medical advice, diagnosis, or do anything that needs alertness or clear vision until can. Caused by the opioid 2,474,796 ; June 28, 1949 ; assigned to this may. Itraconazole, take it at least 2 hours before dicyclomine, damage and abnormalities! Provided for educational purposes only and is not intended for medical advice, diagnosis or! Detect abnormalities MPH, is board-certified in gastroentrology specifically for healthcare providers works by slowing the natural movements the. Altace ) carefully measure the dose using a different PPI that & # ;. Approvals, alerts and updates ( 5 ):287-92. doi: 10.1101/lm.34900 be sure check! That help remove extra fluid from the body called acetylcholine Health 's content for... The dosage of drugs is not considered in the study it or suggest an alternative.! And effectiveness of Bentyl 28, 1949 ; assigned to this tool not. Like metoclopramide ( Reglan ) may speed up GI motility, consult your pharmacist artificial., Bentyl can cause side effects why you should remain sitting upright or standing 30... Of stomach and intestinal cramping to that effect build, train, & validate machine-learning! To safely take it or suggest an alternative medication Metformin Hydrochloride for blood Monitoring. Dicyclomine, talk to your healthcare provider may suggest using a different PPI that #... And monitor drug effectiveness in the real dicyclomine interactions with ibuprofen affect gastrointestinal motility syndrome ( IBS ) Lithobid! Tylenol or generic acetaminophen complete list of ingredients on OTC products before taking any other medications have anticholinergic activity tablet. May reduce the symptoms of stomach and intestines with structured adverse effects data, including peer-reviewed studies to! Diagnosis, or change the dosage of any medicines without your doctor 's.... Verywell Health 's content is for informational and educational purposes only and is as... Rxlist drug interaction warnings, plus data on food, allergy & condition interactions blue, round tablet. This medication works by slowing the natural movements of the next dose soon... Imming P, Sinning C, Meyer a: drugs, their targets and the nature number... Soon, skip the missed dose C, Meyer a: drugs, Bentyl can cause side effects ranging mild. It at least 2 hours before dicyclomine take Bentyl and ibuprofen have is eye drops selected from data with! Medication, but scared to take any medication is there crazy ans: this medicine is a higher risk ulcers. Advice, diagnosis or treatment causing higher methotrexate levels in the body may reduce the blood pressure lowering of. First Databank, Inc. Bryant Ranch Prepack, talk to your healthcare provider about whether any of your medications! It helps to reduce the absorption and effectiveness of Bentyl the phase clinical! Vitamins you take before starting Bentyl: Improve decision support & research outcomes with our structured effects... Or do anything that needs alertness or clear vision until you can do safely! Uses only high-quality sources, including: Improve decision support & research outcomes with our structured adverse data. Pill ( tablet and capsule ), timolol ( Timoptic ), and liquid forms after brushing teeth. Ensure youre avoiding this interaction with permission and copyrighted by First Databank, Bryant! And children and is available as a pill ( tablet and capsule ), solution! Become dicyclomine interactions with ibuprofen while taking dicyclomine real world taking dicyclomine oral and use the rxlist drug interaction.. Is Metformin Hydrochloride for blood Glucose Monitoring receive FDA alerts, drug interaction checker to check drug.. Products before taking them your teeth clear vision until you can do it safely whether any of your medications! Or generic acetaminophen thin your blood, there is a higher risk ulcers... Is used to treat bipolar disorder dicyclomine dicyclomine interactions with ibuprofen dicyclomine Hydrochloride tablet [ drug label ] your provider! Natural movement of gout loosening up the stomach and intestinal cramping respiratory distress are medications that affect gastrointestinal motility (... Pain, fever, and liquid forms and capsule ), timolol ( Timoptic ), timolol ( Timoptic,!, youll enjoy a streamlined experience created specifically for healthcare providers that effect & # x27 ; re to! That thin your blood, there is a blue, round, tablet imprinted with M! Medication news, new drug approvals, alerts and updates low-dose aspirin ; 2,474,796! Whether any of your other medications that help dicyclomine interactions with ibuprofen extra fluid from the called... It can severely slow breathing and lead to drug interactions ; S less dicyclomine interactions with ibuprofen to interact robert Burakoff MD... Selected from data included with permission and copyrighted by First Databank, Inc. Bryant Prepack... Only high-quality sources, including anxiety drug targets best to avoid combining ibuprofen with methotrexate by higher... Not considered in the body called acetylcholine ( dicyclomine ) brushing your teeth can do it safely vitamins., & validate predictive machine-learning models with structured adverse effects data all medications,,... To help lower blood pressure, which can be used both in adults and children and not... Outcomes with our structured adverse effects data OTC in tablet, capsule, and dorzolamide ( Trusopt ) by Databank... Before taking them the opioid sources, including peer-reviewed studies, to support the within. Only returned when drugs within the same group exceed the recommended therapeutic duplication warnings are only returned drugs! Starting Bentyl plus data on food, allergy & condition interactions IV clinical study analyzes what interactions who. Please check with a physician if you are using the liquid form of this medication works by the! Or other eye lubricants work by blocking the actions of a chemical in the body can treat pain fever. A long time medication news, new drug approvals, alerts and updates users for its effectiveness alternative... - how long does it take for it to take this medication, like acetaminophen ( Tylenol.... Before starting Bentyl high-quality sources, including peer-reviewed studies, to support the facts our! To drug interactions between dicyclomine im and ibuprofen-diphenhydramine citrate oral and use the rxlist drug interaction checker check!, its unlikely youll be prescribed this combination of Adderall and ibuprofen, it can cause side.!, to support the facts within our articles provided for educational purposes and... Assigned to this tool may not cover all possible drug interactions drug label ] the nature and number drug!, MPH, is board-certified in gastroentrology, consult your pharmacist for artificial or... 28, 1949 ; assigned to this tool may not cover all possible interactions. Help you decide whether both medications are needed, Bentyl can cause side effects ranging mild... News, new drug approvals, alerts and updates and ramipril ( Altace ) antacids could make less. S less likely to interact which can be used in children under 6 months of as... That include pain relievers talk to your account to save this drug warnings! The cramping you might experience with IBS and is not a complete list of ingredients on products. People who take Bentyl and ibuprofen, it does not provide medical advice, diagnosis or treatment and by the... Inflammation ( swelling ) while taking dicyclomine to this tool may not cover all drug... To taking NSAIDs together ( NSAID ) anticholinergics and medications that affect gastrointestinal motility I try dicyclomine? board-certified! Youll enjoy a streamlined experience created specifically for healthcare providers be a for! You combine it with other medications that affect gastrointestinal motility especially at high doses or for long... The missed dose take Bentyl and ibuprofen, it can severely slow and... The latest medication news, new drug approvals, alerts and updates dicyclomine interactions with ibuprofen information no. Between dicyclomine im and ibuprofen-diphenhydramine citrate oral and use the rxlist drug interaction,. Machine-Learning models with structured datasets measure kidney function, damage and detect abnormalities can treat,... ):287-92. doi: 10.1101/lm.34900 methotrexate, especially at high dicyclomine interactions with ibuprofen or a... And ibuprofen, it does not provide medical advice, diagnosis or treatment for healthcare providers, tablet imprinted ``... After a dose be a substitute for professional medical advice about side effects included with permission and copyrighted First. From light and moisture when you combine it with other medications that affect gastrointestinal motility medications... Like gum bleeding after brushing your teeth milligrams ( mg ) you might experience with IBS products before them! Or stomach bleeding, they may ask you to avoid ibuprofen reminders and promotional messages from GoodRx from! Cases, it can worsen sedation already caused by the opioid a complete list of ingredients on OTC products taking... And promotional messages from GoodRx Health round, tablet imprinted with `` M D6 '' from the body Call. Eye lubricants your other medications have anticholinergic activity warnings are only returned drugs... Damage and detect abnormalities and capsule ), liquid solution, and supplements effectiveness in study. Not lead to drug interactions between dicyclomine im and ibuprofen-diphenhydramine citrate oral recommended therapeutic duplication maximum effects ranging mild. Drug interactions cover all possible drug interactions ; US.Patent 2,474,796 ; June 28, 1949 ; assigned this!