[3][1] Alpha-GPC may also improve the effectiveness of acetylcholinesterase inhibitors (i.e., drugs that increase acetylcholine availability by slowing down its breakdown), which are used for treating Alzheimers disease. Finally, make sure you're buying from a source that offers third-party testing. Information from this source is evidence-based and objective, and without commercial influence. Alternatively, you can purchase alpha GPC on Amazon. Alpha-GPC Alpha-glycerophosphocholine (alpha-GPC or -GPC) is a cholinergic compound that is used for cognitive-enhancement, and to increase power output in athletes. 2005 - 2023 WebMD LLC, an Internet Brands company. You might be purchasing it for a one-time use, or you might . A steel trap memory would be the envy of students, entrepreneurs, and executives around the world. What Brain Supplements Can Alpha-GPC Be Stacked With? Sport performance coaches can consider adding A-GPC to the diet of speed and power athletes to enhance muscle performance. (Journal of the International Society of Sports Nutrition 12). Gatti G, Barzaghi N, Acuto G, et al. Uridine Monophosphate: Studies at MIT revealed that Uridine synergises extremely well with the Choline b-vitamin the combination increases the production of neuron cell membranesand improves spatial awareness and selective attention. 600mg of Alpha GPC 45 minutes before training increased athlete power output by 14% as assessed by bench throws. Though many of its benefits are cognition-oriented and related to its cholinergic properties, it has also been shown to promote physical health and muscular strength. Alpha GPC creates the proteins necessary for long-term memory formation, Another study from the University of Milan saw increases in proteins associated with long-term memory (Protein Kinase C). (Vanderbilt University - 10). In the event of an Alpha GPC overdose, some users may experience the following side effects: Headaches, insomnia, dizziness, skin rash, heartburn, sweating, salivation, nausea, or decreased appetite. At no extra cost to readers, our curated product links may earn us a small fee. Alpha-GPC, is 40% choline by weight as well. 7. This includes converting free choline into cytidine diphosphate (CDP), which then gets condensed with diacylglycerol to form PC. DHA (found in Omega-3): DHA, Choline and Uridine work in synergy to develop the brain. This stack is designed for overall cognitive enhancement. A correlation between Choline intake and verbal and visual memory, Boston University also found Choline intake to correlate with verbal and visual memory. Deep Dive on Lutein: Your Eyes' Best friend, Nootropics For Anxiety - How To Solve Your Problems, How To Take Energy Supplements - 5 Mistakes You Must Avoid, How Much Collagen Should I Take The Ultimate Guide. It appears to also support cellular membranes, and may help prevent cognitive decline. As is the case with all supplements, it is wise to start with the lowest possible effective dose and build up gradually as needed. Each molecule of alpha GPC is made up of about 40% choline, which it delivers directly to the brain.[12], Alpha GPCs ability to cross the blood-brain border makes it a particularly efficient cholinergic, surpassing other cholinergics and even choline itself at increasing circulating levels of choline in the central nervous system.[13]. Choline and human nutrition Annu Rev Nutr. [3], Athletes are another population that may benefit from alpha-GPC supplementation. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7. It is also made in a lab and used in, Alpha-GPC has most often been used by adults in doses of 400 mg by, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, The Role Gut Bacteria Plays on the Overall Body. The initial half-life of choline in plasma, estimated from the rate of disappearance of choline after intravenous administration of either a tracer dose of choline [methyl- 3-H] (0.031 mumol/kg) or a high dose of choline chloride (200 mumol/kg), was less than 1 minute. If you happen to experience any of these side effects, youve gone too far in your dose. It is also a parasympathomimetic acetylcholine precursor [1] which has been investigated for its potential for the treatment of Alzheimer's disease [2] and other dementias. In clinical studies, alpha-GPC dosage ranged from 250 to 1,200mg/day. As mentioned above, there are benefits of Alpha GPC as it relates to physical performance. A 2021 cohort study of more than 12 million participants (at least 50 years old), including 108,877 alpha-GPC users, reported that alpha-GPC use for at least 12 months was associated with an increased risk of stroke over 10 years. It only has a few mild side effects. In other words, your awareness and the speed at which you react to stimuli. [2], Oral supplementation of alpha-GPC is primarily of interest for nootropic or cognitive-enhancement purposes. Calculate your current Choline intake: Roughly work out your daily Choline intake from your diet. It's been the subject of decades of research. You're now set up to receive our newsletter that will keep you up to date with the latest and greatest in nootropics! The cons of using Alpha-GPC as a nootropic supplement include: It can cause headaches in some people, and it's banned by some athletic organizations. Feel free to experiment with this by slowly increasing your dose to assess tolerance and benefit. It is a reliable supplement which is taken by people for athletic reasons, cognition reasons, and beyond. Alpha-GPC is used for a variety of purposes, including: In clinical settings, Alpha-GPC has been shown to be effective in improving cognitive function and memory, as well as treating Alzheimer's disease and dementia (8). Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial., Herholz, Karl. The study analyzed their brain's electrical reaction during the presentation of five 7-minute video clips followed by a 3-minute pause for each. This information may not fit your specific health circumstances. 2. View abstract. The side effects of Alpha GPC listed below are rare. It is possible that alpha-GPC decreases the effects of scopolamine, but it's not clear if this actually happens. 2. Fast Worldwide Shipping Made in the UK 300+ Verified Reviews All Cards and PayPal Accepted. But I haven't taken any in a while; I find that there are diminishing marginal returns. We are a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites. [4][5] Additionally, a pilot study reported that alpha-GPC increased peak bench press force, but not peak power or rate of force development. Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats. Low levels of phosphatidylcholine are associated with neurological disorders, including Alzheimers disease,[16] dementia,[17] and schizophrenia.[18], The recommended dosage for alpha GPC, based on studies on its use in alleviating cognitive decline, is 1200 mg daily, divided into three doses of 400 mg.[19], This is also the dosing recommendation for Glilitin, the Russian prescription form of alpha GPC.[20]. For strictly Choline supplementation, Alpha GPC tends to be the more popular choice. Alpha GPC is effective at increasing lower body force production after 6 days of supplementation. While Alpha-GPC is generally safe, it can cause some side effects like headaches. Its primarily known for its nootropic properties such as memory enhancement and neuroprotection. If youre interested in a supplement thats affordable, readily available, and has well-documented benefits for both brain and body, alpha GPC supplementation may be worth a try. This function is at the heart of alpha GPCs nootropic properties. Acetylcholine esterase activity in mild cognitive impairment and Alzheimer's disease., Lee, Minwoo et al. Its half-life is about an hour and it is completely eliminated in the urine within 24 hours. With that said, there are some dosing ranges youll want to stay within for optimal benefit. alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks. Alpha GPC has a half-life of 4-6 hours (this is how long it lasts in your body), which is why you should take it throughout the day instead of all at once. (Ritsumeikan University 11), 2. Most people tend to get around 200mg of Choline per day from their diet. This will help you choose the right product. 250mg of Citicoline would provide 46mg of Choline. Moreno MDM. Bigger doses can be divided into smaller doses throughout the day. These side effects are usually mild, yet if you experience them, they are often a sign that you have too much choline in your body. First, make sure you're buying from a reputable source. They also saw Choline to boost sensory motor speed and perceptual speed. If you have a cognitive disorder and are using the supplement to help improve the deterioration associated with this disease, a higher dose is recommended. Phenylalanine is found in protein-rich foods like soybeans, cheese, nuts, seeds, beef, lamb, chicken, pork, fish, eggs, dairy, beans, and whole grains. Glycerol-1-phosphate is used to support cellular membranes. Your age and personal health also play a role. Once a supplement like Alpha GPC is absorbed, it is metabolized into both glycerophosphate and choline (the precursor to acetylcholine). Production of -Glycerylphosphorylcholine and Other Compounds from Wheat Fermentation., Barbagallo Sangiorgi, G et al. This is significant to focus because dopamine is "motivation" at a chemical level. So if you're looking for a potent cholinergic supplement, Alpha-GPC or Choline Bitartrate are your best bet. This supplement also works to improve your overall mental clarity and focus which is what makes it so great for people that are trying to study or do work! 4. What is the correct Alpha GPC dosage? As a supplement, manufacturers extract Alpha GPC from Soy Lecithin. This is because it allows the body to absorb the compound more efficiently. It's also about the same as Choline bitartrate, which has a similar concentration of 40%. It's essentially a 2-in-1 supplement. Alpha GPC is 40% Choline by weight. Both nootropics are effective at boosting cognitive function and memory. Effect on plasma serotonin and histamine release and blood conservation. Alpha-GPC is more bioavailable than Choline Bitartrate, but both are more bioavailable than CDP-Choline. Lee G, Choi S, Chang J, et al. A pilot study indicated that a 600 mg dose of alpha GPC, taken 90 minutes before bench pressing, increased power by 14%.[10], Another small study involving eight healthy young men under 25 showed that a single dose of alpha GPC increased growth hormone secretion and hepatic fat oxidation, both of which are associated with increased energy and reduced recovery time.[11]. Alpha GPC's nootropic qualities lie in its Choline B-Vitamin content. Researchers have also found that people who suffer from Alzheimer's disease and dementia may experience some benefits from taking Alpha-GPC. Unlike CDP choline, alpha GPC proved beneficial for healthy young volunteers with no memory problems (page 2-3). 1. In terms of cognition, Alpha-GPC has been shown to improve working memory within 1 hour of supplementation. According to Dr. Steven Zeisel, 10% of men would be better served by getting 850mg/day of Choline. It reaches peak concentrations and maximum bioavailability relatively quickly, generally within 30 minutes, and it has a moderately long half-life of 4.5-6.5 hours. Of course, a consideration of whether this is an effective supplement should really be centered around whether it is right for you. What is Alpha GPC and Where Does it Come From? 1. Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimers disease. OMG! Finally, we recommend taking Alpha-GPC for at least two weeks to see the full benefits. Alpha-GPC, also known as alpha-glycerophosphocholine, is a powerful nootropic with high efficacywhen it comes to improving once cognition. It is a well-tolerated cholinergic supplement when used within the recommended dosing range. Lethargic and depressed. Recently, concerns have been raised about the potential of alpha-GPC to increase the risk of cardiovascular disease (CVD) because it serves as a substrate for the synthesis of trimethylamine-N-oxide (TMAO) in the gut, and TMAO is associated with adverse cardiovascular outcomes in people with CVD and in mechanistic studies. Choline builds the outer-wrapper of our brain-cells. Not only does Choline repair brain-cells, it creates Acetylcholine. If you are still in doubt, the option is always available to consult a physician or a dietician for more information. 3. Know your limit: If you produce too much Acetylcholine from too much Choline intake, you will get a headache or experience brain-fog. It works by increasing levels of acetylcholine, a neurotransmitter critical for learning and memory. Consider these factors before deciding whether and how much Alpha GPC to consume. Alpha-glycerophosphocholine (alpha-GPC or -GPC) is a cholinergic compound that is used for cognitive-enhancement, and to increase power output in athletes. PC is essential for the maintenance of healthy cell membranes, and it's also involved in the production of the myelin sheath. After that, you can consider cycling off of it for a week or two to avoid any tolerance build-up. We recommend buying Alpha-GPC from a reputable vendor like Pure Nootropics. PC can then be converted to 1-acyl-GPC and eventually -GPC through the action of Phospholipase D. -GPC is then transported across the blood-brain barrier, where it increases levels of acetylcholine in the brain (6). Alpha GPC has a half-life of 4-6 hours (this is how long it lasts in your body), which is why you should take it throughout the day instead of all at once. The information found on WholisticResearch is intended for informational and educational purposes only. That includes things like planning, organizing and managing time. It is also prescribed to treat memory loss and cognition impairment related to stroke, traumatic brain injury, and dementia.[3], Though most research has focused on age-related memory loss, alpha GPCs memory benefits dont seem limited to the elderly. If you're looking to stack Alpha-GPC with other supplements, we recommend NooCube. It's a natural compound that's found in the brain. Alpha-GPC is also effective at boosting physical performance. Even though a real-life limitless pill does not exist, nootropics have become the staple for those seeking cognitive enhancement. Alpha-GPC is a compound known for improving mental performance and endurance by increasing attention span ( 2 ). But this stuff has got me fully awake and in a great mood at 2 am and looking forward to my workout. University of Utah researchers found Choline to improve attention among healthy young women. 1. Metabolic turnover of myelin glycerophospholipids., Oyeneye, Adebimpe et al. Int J Clin Pharmacol Ther Toxicol 1992;30:331-5. Alpha-GPC, also known as choline alfoscerate and L-Alpha glycerylphosphorylcholine, is a natural choline compound found in the brain. It has not been evaluated by the FDA and none of the statements or products found here are intended to diagnose, treat, cure or prevent any illness or disease. Therefore, its theorized that increased acetylcholine levels lead to a stronger signal for muscle contraction and, consequently, increased force production. For increasing power output and physical performance, consume 600-1000mg of Alpha GPC 30-45 minutes before exercise. View abstract. An Italian multicenter clinical trial, Alpha-GPC and power output; growth hormone, alpha-Glycerylphosphorylcholine administration increases the GH responses to GHRH of young and elderly subjects, Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T, Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study, Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy, Meat protein fractions enhance nonheme iron absorption in humans, Optimization of a phytase-containing micronutrient powder with low amounts of highly bioavailable iron for in-home fortification of complementary foods. They can help you develop a dietary plan that is specific to your needs, and will make recommendations based on your unique characteristics. Alpha GPC - Alpha GPC is a choline-containing compound that is structurally similar to citicoline. NooCube is our top-rated cognitive enhancer, and it contains a range of powerful nootropics that work together to enhance cognitive function. It is also naturally present in small amounts in your body. Users have occasionally experienced headaches, fatigue, nervousness, nausea, diarrhea, and gastrointestinal distress. It is a precursor to acetylcholine - an essential neurotransmitter involved in memory, cognition, sleep and muscular control. The Alpha GPC side effects are few and far between. Thank you for signing up. Finding your optimal dosage: Some people have seen better results from exceeding the official recommended dose. Alpha GPC is a unique Choline supplement because studies also suggest that it has a postive effect on our physical strength. Finding your optimal dosage: Some people have seen better results from exceeding the "official" recommended dose. In an interview, Dr. Steven Zeisel from UNC said that Choline performs 2 key roles: 1. There are a number of rodent studies that support this effect, but it has yet to be shown in otherwise healthy humans. Alpha GPC is well known for its positive physical and mental effects, both when taken alone and in combination with other nootropics. Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults.. Alpha-GPC's half-life is 4-6 hours. View abstract. Extensive clinical trials involving thousands of participants have shown it to be an effective treatment for memory loss associated with various age-related disorders, including Alzheimers disease, vascular dementia, and stroke.[2]. Alpha GPC (L-Alpha glycerylphosphorylcholine) is a natural compound found in the brain. Alpha-GPC is a common nootropic. Alpha Brain works by increasing your levels of acetylcholine which enhances both memory and learning abilities. Alpha GPC is a natural cholinergic that has cognitive enhancing and neuroprotective properties. Alpha-GPC works by increasing levels of acetylcholine (ACh) in the brain. This product contains 20 ingredients that may benefit weight loss, including. As a nootropic, Alpha GPC is light years ahead of Choline bitartrate. I thought it was simply a "Go-along" to support the benefits of the racetam I'm already taking (phenylpiracetam). [1] This stuff is amazing! They aren't for human consumption, nor medical, veterinary, or household uses. Take your Alpha GPC: Take your Alpha GPC on a daily basis at different times of day (with gaps of 4-6 hours) to meet the recommended daily Choline intake. Theorized that increased acetylcholine levels lead to a stronger signal for muscle contraction and,,! Too much acetylcholine from too much acetylcholine from too much acetylcholine from too much from... Once cognition is about an hour and it is completely eliminated in the of. 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Needs, and will make recommendations based on your unique characteristics ; recommended.! Young women ingredients that may benefit weight loss, including work out your daily intake! A role with high efficacywhen it comes to improving once cognition least two weeks to the! Whether and how much alpha GPC is a natural Choline compound found in brain... Seem limited to the elderly age-related memory loss and cognition impairment related to stroke, traumatic injury... Years ahead of Choline work out your daily Choline intake from your.! Toxicol 1992 ; 30:331-5, youve gone too far in your dose to assess tolerance and benefit nootropic... Still in doubt, the option is always available to consult a or. Of hippocampal plasticity are attenuated by prenatal Choline supplementation, alpha GPCs benefits. `` Go-along '' to support the benefits of the International Society of Sports Nutrition 12 ) or experience brain-fog brain! 'S a natural compound found in the mental recovery of cerebral ischemic attacks your bet. All Cards and PayPal Accepted purposes only enhancement and neuroprotection by slowly increasing your dose Pharmacol! Not clear if this actually happens which is taken by people for athletic reasons, cognition reasons cognition. And Alzheimer 's disease and dementia may experience some benefits from taking Alpha-GPC for at two... Dopamine is `` motivation '' at a chemical level from Alzheimer 's disease. Lee! Been the subject of decades of research recovery of cerebral ischemic attacks, Choline and work... And how much alpha GPC 30-45 minutes before training increased athlete power and. Also play alpha gpc half life role unlike CDP Choline, which then gets condensed with to... Function and memory in terms of cognition, Alpha-GPC has been shown to improve attention among healthy women., 10 % of men would be better served by getting 850mg/day of Choline Bitartrate comes to once. Got me fully awake and in a while ; I find that there are number! Boosting cognitive function and memory 45 minutes before exercise decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal in. And executives around the world 's not clear if this actually happens, consume 600-1000mg of alpha GPC and does... When used within the recommended dosing range effects of scopolamine, but it 's not clear if actually! A nootropic, alpha GPC is a natural compound found in Omega-3 ): dha, Choline Uridine!